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  • CINaM
  • Campus de Luminy
  • Case 913
  • 13288 Marseille Cedex 9
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  • Tel : +33(0)4 91 17 28 00
  • Fax : +33(0)4 91 41 89 16

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Nom : Viallat
Prenom : Annie
Tel : +33(0)6 83 09 25 74
Fax : +33(0)4 91 41 89 16
E-mail : viallat@cinam.univ-mrs.fr

Physique et nano-micro Ingénierie pour le Vivant

Research topics

 

Current Research Area : Active Matter - Biofluid Physics – Cell Rheology – Fluid and elasticity in living systems

 

Soft micro-shells, artificial capsules, liposomes, encapsulation.

Red blood cells dynamics in flow: Lift force – Cell Biomechanics –Sedimentation – fluid structure interaction

Blood cell Dynamics in the microvasculature: Microfluidics- red blood cells in submicron splenic slits - vasoocclusion in sickle cell anemia, blood cells adhesion and margination 

Physics of the mucociliary transport:  collective behaviour of bronchial cilia, flow patterns, coupling between ciliary activity and mucus transport

 

 

Current research

 Soft micro-shells, micro-beads, liposomes, encapsulation

                          Viscous and Gelly giant vesicles – Standards for comet assays – Artificial vacuoles for living parasites

GUV and Red blood cells dynamics in flow

                          Lift force – Cell Biomechanics –Sedimentation -

Red and White Blood Cells Dynamics in biomimicking capillary networks

                          Microfluidics – Cell Rheology – Transport in the Vasculature

Artifical vacuoles for Leishmania

Severe asthma: physicial aspects of the mucociliary transport

            Microrheology – cilia beats– application for severe asthma

 

Research experience

Biography

Annie Viallat is engineer of Ecole Polytechnique (Paris, France). She received her PhD in Physics from the University of Grenoble (France) in 1987, working on polymer gels and NMR. After a postdoc on theory of conjugated polymers in the Materials Departments (UC Santa Barbara), she joined the Spectrométrie Physique lab (Grenoble) in 1989, studying polymer gels and heterogeneous polymer solutions. Her research moved to biological physics in 1999. From 2005 to 2015 she led a group in Marseille on the dynamics in microflows of vesicles and blood cells. Since 2016, she is the head of department ‘Physics and Engineering for Living Matter’ in CINaM (Marseille), working on active matter, microcirculation of red blood cells in disease and physics of the mucociliary clearance.

 

 

Positions

2016-  Head of department at CINaM Physics and nano/micro engineering of living systems,

2007-2014 Director of the CNRS French Consortium ‘Physics from Cell to Tissue’

2005-2015 Group leader ‘biomimetics’, Adhesion & Inflammation lab., Marseille Biophysics-Biomechanics

1999-2002 Group Leader, Laboratoire Spectrométrie Physique, Grenoble, Polymers, Giant Lipid vesicles

1989-1999 Junior Research Scientist, Laboratoire Spectrométrie Physique, Grenoble

 

Academic degrees

1982 Engineer Ecole Polytechnique, Paris 
1984 Engineer: Rural Eng., Water, Paris 

1984 Master in Solid State Physics, Paris 7

 

Awards: PhD fellowship Rhône Poulenc (1985), Postdoc fellowship UCSB, Material Department (1988), PES CNRS 2010-2013,

Grants: 2002 IPMC Grenoble, 2003 Region RhôneAlpes, 2004 CPER RhôneAlpes, 2004 PIR microfluidique, 204 AC CNRS, 2004 IT2B, 2009 ANR, 2010 PACA region, 2010 C’Nano PACA, 2011 CNRS prise de risque,  2011 CAPES-COFECUB program, 2013 ANR, 2013 AMidex*

Management-expertise: ANR (France), NSF (USA), FET program (European Commission), Comité National (CNRS), CNU, AERES

 

 

Recent publications

2019

« Self-organization of red blood cell suspensions under confined 2D flows" »
Cécile Iss, Dorian Midou, Alexis Moreau, Delphine Held, Anne Charrier, Simon Mendez, Annie Viallat, Emmanuèle Helfer
Soft Matter (2019)10.1039/C8SM02571A

2018

« Spatiotemporal organization of cilia drives multiscale mucus swirls in model human bronchial epithelium" »
Mustapha-Kamel Khelloufi, Etienne Loiseau, Marc Jaeger, Nicolas Molinari, Pascal Chanez, Delphine Gras, Annie Viallat
Scientific Reports 8:2447 (2018)10.1038/s41598-018-20882-4

« When giant vesicles mimic red blood cell's dynamics: swinging of two-phase vesicles in shear flow" »
Simon Tusch, Etienne Loiseau, Al-Hair Al-Halifa, Kamel Khelloufi, Emmanuèle Helfer, Annie Viallat
Physical Review Fluids 3 (2018)10.1103/PhysRevFluids.3.123605

2017

« High Aspect Ratio Sub-Micrometer Channels Using Wet Etching: Application to the Dynamics of Red Blood Cell Transiting through Biomimetic Splenic Slits" »
Priya Gambhire, Scott Atwell, Cécile Iss, Frédéric Bedu, Igor Ozerov, Catherine Badens, Emmanuèle Helfer, Annie Viallat, Anne Charrier
Small 13:1700967 (2017)10.1002/smll.201700967

2015

« Encapsulation of Living Leishmania Promastigotes in Artificial Lipid Vacuoles" »
Carlos E. S. Guedes, Jose G. B. Lima, Emmanuèle Helfer, Patricia S. T. Veras, Annie Viallat
PLoS ONE 1-12 (2015)10.1371/journal.pone.0134925

« Serum Pantetheinase/Vanin Levels Regulate Erythrocyte Homeostasis and Severity of Malaria" »
Samuel Rommelaere, Virginie Millet, Pascal Rihet, Scott Atwell, Emmanuèle Helfer, Lionel Chasson, Carole Beaumont, Giovanna Chimini, Maria Do Rosario Sambo, Annie Viallat, Carlos Penha-Goncalves, Franck Galland, Philippe Naquet
American Journal of Pathology 185:3039-3052 (2015)10.1016/j.ajpath.2015.07.011


Keywords

biological physics –Fluid and elasticity in cells - Membranes – cell rheology