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Accueil du site > À la une > Mix and Match : Co-assembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular and Controllable Interfaces

Mix and Match : Co-assembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular and Controllable Interfaces

Samuel S. Hinman, Charles J. Ruiz, Yu Cao, Meghann C. Ma, Jingjie Tang, Erik Laurini, Paola Posocco, Suzanne Giorgio, Sabrina Pricl, Ling Peng*, and Quan Cheng*

ACS Appl. Mater. Interfaces. 2017, 9, 1029-1035. (DOI : 10.1021/acsami.6b11556)

Self-assembly of supramolecular structures has become an attractive means to create new biologically inspired materials and interfaces. We report the first robust hybrid bilayer systems readily co-assembled from amphiphilic dendrimers and a naturally occurring phospholipid. Both concentration and generation of the dendrimers have direct impacts on the biophysical properties of the co-assemblies. Raising the dendrimer concentration increases the hybrid bilayer stability, while changes in the generation and the concentration of the embedded dendrimers impact the fluidity of the co-assembled systems. Multivalent dendrimer amine terminals allow for nondestructive in situ derivatization, providing a convenient approach to decorate and modulate the local environment of the hybrid bilayer. The co-assembly of lipid/dendrimer interfaces offers a unique platform for the creation of hybrid systems with modular and precisely controllable behavior for further applications in sensing and drug delivery.

This work is issued from collaboration between Dr. Ling Peng at the CNRS/Aix-Marseille University in France and Prof. Quan Cheng at University of California – Riverside in USA together with Prof. Sabrina Pricl at Trieste University in Italy.

Contact : Ling Peng

Ref : Hinman et al, ACS Appl. Mater. Interfaces. 2017, 9, 1029-1035. (DOI : 10.1021/acsami.6b11556)

JPG - 101.8 ko

2017ACSAMI-1 - 2.8 Mo